This study investigated the cause of early mortality of spouses in Ogun State, Nigeria. Two thousand respondents of age below 50 specifically 20-49 surviving spouses were selected for the study, using a purposive sampling technique. The instrument for data collection was on Cause of Death Inventory. Demographic characteristics of the respondents were carried out on Age and that of the deceased at the time of death, sex, occupation and the Cause of Early Death of respondent’s spouses was analyzed using Percentages to describe the data. The study found that the main cause of early death of spouses in Ogun State was sudden death/cardiac arrest 42.8% (858) followed by accident 644(32.2%)terminal illness 296(14.8%), witchcraft 84(4.2%), genotype (SS) 48(2.4%), suicide 28(1.4%), carelessness 32(1.6%) and hereditary 12(06%). The study thus recommended that people should be going for regular medical checkup even when they are not sick, consult their physician when they notice any strange things or feelings in their body, people should avoid anger, worry and take life generally easy, people should avoid violations of safety rules and avoid alcohol consumption when driving, people should not over work, rest when fatigue, people should be very close to their creator by praying fervently, people should know their genotype before getting married to avoid giving birth to(SS)children ,people should take seriously every suicidal threat or act, people should not be careless about their health and to engage in regular exercises.
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