The study assessed occupational stress and its effects on job performance among members of staff at Takoradi Polytechnic. Six research questions and two hypotheses were raised to guide the study and a descriptive survey was used. The target population for the study was the members of staff of Takoradi Polytechnic comprising junior staff, senior staff, and senior members in the polytechnic. Random sampling technique was used to draw 250 members of staff for the study. Questionnaire was the main instrument used to gather the data. Descriptive statistics (tables and correlation) were used to analyze data pertaining to the research whereas inferential statistics (Pearson’s chi-square) was used to analyze data pertaining to the hypotheses. The result showed that fatigue was the major cause of occupational stress among staff of the polytechnic followed by back pain, an effect of long sitting hours on uncomfortable chairs at work. There was not a significant difference existed between male and female members of staff. A key recommendation from the study was that correct stress management training program should be incorporated into the fabric of the Polytechnic administration to improve health of workers and interpersonal relationships.
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