The study explored the psychosocial perspectives of stigmatization and discrimination of Persons Living with HIV (PLWHA) in the Effutu Municipality with Winneba Municipal Hospital in focus. The research design employed was the descriptive survey using the explanatory mixed method approach which utilized questionnaire and interview as the research instruments for data collection. Two (2) research questions and two (2) hypotheses guided the study. Fifty-three (53) participants comprising fifty-one (51) PLWHA and two (2) HIV counsellors were sampled using the convenience, purposive, and snowball sampling techniques. Data were analyzed using inferential statistics (t-test & regression) to test the hypotheses while the qualitative data were analysed thematically with verbatim quotations from participants to support issues as they emerged. The study revealed that stigmatization and discrimination against PLWHA are not significant even though there was evidence of their existence in the areas of employment and workplace, community contexts, family contexts, and access to healthcare. It was, therefore recommended that the local authorities together with the District Ghana AIDS Commission should strengthen the awareness creation on the need for harmonious living with PLWHA in the community and the District Ministry of Health should employ more health personnel to engage in follow up services to PLWHA patients.
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