Evaluation of the Pharmacological Activities of Beta-Sitosterol Isolated From the Bark of Sarcocephalus Latifolius (Smith Bruce)

Abstract

Beta Sitosterol was previously isolated from the bark of Sarcocephalus latifolius (smith Bruce). This  was subjected to antimicrobial screening with the following microorganisms to determine its pharmacological activities; Methycilin Resistant Staphylococcus aureus (MRSA), Staphylococcus aureus, Streptococcus pyrogenes, Bacillus subtilis, Corynebacterium ulcerans, Escherichia coli, proteus mirabilis, proteus vulgaris, Pseudomonas aureginosa, Salmonella typhi, Shigellia dysenteric, Candida albicans, Candida virusei, and Candida tropicalis. The zone of inhibition was observed to be between 20 to 27 mm with Bacillus subtilis and Salmonella typhi to be the most sensitive organism with the highest zones of inhibition of 27mm. The Beta Sitosterol was found to inhibit Staphylococcus aureus, Streptococcus pyrogenes, Bacillus subtilis, Corynebacterium ulcerans, vulgaris, Pseudomonas aureginosa, Salmonella typhi, Shigellia dysenteric, Candida albicans and Candida virusei at 12.5µg/ml. While the MBC/MFC was minimum for Bacillus subtilis ,Salmonella typhi and Shigellia dysenteric at 25µg/ml, and Staphylococcus aureus, Streptococcus pyrogene, Corynebacterium ulcerans, Proteus vulgaris, Proteus aureginosa, Candida albicans and Candida virusei were at 50µg/ml. The result further shows that it could be compared with a standard drug.

Keywords: : Pharmacological, Anti-Cancer, Beta-Sitosterol, Microorganism, Sarcocephalus

Article Review Status: Published

Pages: 8-15 (Download PDF)

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