Malaria is vector borne disease. Even though there is global reduction in malaria mortality still the African Region continues to shoulder the heaviest burden: in 2015, this one region accounted for approximately nine in 10 malaria cases and deaths globally. Methods: The main aim of this study was to assess four year pattern and trends of malaria morbidity and mortality in Tigray region using retrospective study design from patients’ registration and Health Management Information System (HMIS) data. The data was interred and coded to Epi Info and exported to SPSS version 21 for statistics analysis. Result: A total of 1.5 million malaria cases were analyzed. 78% of the cases were confirmed though liberator where as 22% of the cases diagnosis were made though clinical manifestation without liberator. The most common species of malaria morbidity is Plasmodium falciparum which accounts 71% where are the rest were other species. The magnitude of malaria morbidity in 2014/15 is 1.5 times lower than 2011/12. Similarly the magnitude of malaria mortality is 1.74 times lower than 2011/12. Conclusion: Although elimination and eradication of malaria morbidity and mortality were not possible reduction of malaria morbidity and mortality were achieved. But still know it needs high-level and sustained political commitment and constant vigilance, intense programmatic efforts in affected areas for eradication and elimination of malaria.
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