Health information systems (HISs) have transformed health organizations by playing a supportive role in improving efficiency and quality of healthcare. This paper explores the mediating role of perceived usefulness (PU) and perceived ease of use (PEOU) on the relationship between task technology fit (TTF), information quality (IQ), system quality (SQ) and user performance (UP) in health organizations in Kenya. A framework was generated by modifying the dimensions of TTF, DeLone and McLean IS Success Model (D&M) and Technology Acceptance Model (TAM). Descriptive survey design was utilized and the proposed model provided empirical evidence based on a questionnaire administered to 395 HIS users. Mediation analysis was carried out using ordinary least squares (OLS) path analysis and results indicated that PU and PEOU mediated the association between TTF, IQ, SQ and UP. The results indicated that performance outcomes are higher when individual users perceive HISs to be useful and easy to use.
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