Induction of epithelial cell Apoptosis by Acinetobacter baumannii A424


Acinetobacter baumannii is considered as highly contagious pathogen, it can cause serious infections in the Skin, lungs, blood, and brain. It may also cause burn, urinary tract and wound infections. It can be spread by direct contact and may be found on skin or in food, water, or soil. It may also be found in hospitals. Learning how dose A.baumannii effect on cells and program of cell death has been a major research goal for researchers. In current study, we chose Acinetobacter baumannii A424 strain as a model for cell apoptosis since little information are available for this strain. Live bacteria were more likely to produce epithelial cell death after few hours of incubation. Killed and filtrate form of this strain gave moderate apoptotic activity in HACAT cell, degraded DNA of apoptotic cell showed approximately 140 pb in size. In conclusion the ability of A424 strain of Acinetobacter baumannii to cause cell apoptosis as well as other o9ther characteristics like multidrug resistance activity, biofilm formation and survival in desiccation (data not shown) may reflect the virulence characteristics of this opportunistic strain which may infect ill or severely wounded patients

Keywords: Acinatobacter Baumannii, Cell Apoptosis, Virulence Factor

Unique Article ID: EJBMSR-128

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