The study consist of two groups, untreated control of twenty male rats feed on normal diets while treated young and adult 40 male rats feed solely on vegetable oil for six months during treatment. Some animals diet especially young ones. Grossly, macroscopically and microscopically studies were done, treated male rats showed rough greasy hair macroscopically in larged pale yellow liver discoloration. Microscopically, varying degree of vacuolation in hepatocyte associated with renal pathological lesion. Also showed thinning of epiderms reduce hair follicals and atrophic sepaceous gland in the skin, and atrophy of skeletal muscle associated with interstatial odema, and showed vacuolation in stomach (glandular region), small intestine and testis. also showed congestion and thickening bronchiolar epithelium.