Road safety and the increasing death toll on Ghana’s roads remain a prominent, emotive issue with terrible impacts on communities and families. Quality road transport infrastructure is very critical to ensure road safety for all passengers. This study sought to explore the state of transport infrastructure in ensuring passenger safety. The study was conducted in Kejetia, the biggest open bus terminal in Ghana. The study revealed that the most pressing problems faced by operators, passengers and drivers at the lorry terminal include driver parking at any vantage point, vendors taking over the terminal space and the gradual emergence of market in and around the terminal. It also found out that the terminal lacks basic facilities such as a clinic, security post and fire station to provide essential services to all users of the terminal. The terminal also lacks adequate signage to aid in providing a safe haven for passengers and drivers. Management of the terminal as well as city authorities must restructure their local transport policies regarding road terminal operations and re-align, enforce and monitor overall transport operations in the city.