Tag Archives: TNF-α

Association between Cytokine Gene Polymorphism and Recurrent Pregnancy Loss among Basra Province Women (Published)

Forty cases of women sever from recurrent pregnancy loss (RPL) compared with 40 normal women for determining   the cytokine gene polymorphism in the promoter region of : tumor necrosis factor-alpha TNF-α (-308 G/A), interleukin IL-6 (-634 G/C) and IL-10 (-592 C/A) in aborted women of Basra /Iraq. The results indicated that there was an association between RPL and the polymorphisms in inflammatory cytokines (IL-6, TNF-α), while IL-10 gene did not showed  any effect on both cases of RPL and normal cases.

Keywords: Cytokine Genes, IL-10, IL-6, Loss, Recurrent Pregnancy, TNF-α

Immunization Model of Rats Treated With Two Antigens from Mrsa Bacteria Isolated From Burn Patients (Published)

The present study aimed to investigate the efficiency of alpha hemolysin (Hla) and heat inactivate bacteria suspension (HIBS) antigens prepared from Methicillin Resistant Staphylococcus aureus (MRSA) bacteria isolated from burn wound in rats after immunization. Both antigens examined after the period of immunization to determine the total IgG concentration, IFN-γ and TNF-α levels in serum. The results indicated that Hla antigen had the ability to modulate and induce the humoral and cellular immune response since that there was a significant elevation in serum total IgG and IFN-γ at (p≤ 0.05) in comparison with the HIBS antigen. Resent data also indicated to a significant decreasing in TNF-α concentration in sera of rats immunized with two studied antigens Hla (44.54) pg/ml and HIBS (16.5) pg/ml.

Keywords: Alpha Hemolysin, HIBS, IFN-γ, IgG, MRSA, TNF-α