Thalassemia is an autosomal recessive inherited blood disorder due to hemoglobin-production abnormalities. Over the past three decades, hyper-transfusion therapy in these patients has shown significant increase in life expectancy and quality of life. unfortunately, this type of therapy also increased the frequency of complications due to iron overload. The study aims to identify the Sociodemographic and clinical characteristics of patients with thalassemia, and to assess transfusion related complication among them. A descriptive, cross-sectional study was conducted in Thalassemia Center in Al-Najaf province in Iraq, during the period from the 1st of April to the 31st of August 2018. Data were collected through direct interview with patients/parents using a specially designed questionnaire form. A total of 175 transfusion dependent thalassemia major patients were included, the mean age 10. 5 years ranging from 5 m to 34years. Patients under 10 years of age represented the highest rate with Male: Female ratio 1.2:1. 60% were from rural area with high percentage of parental consanguinity (70%). The study documented the relationship between iron over load and appearance of complications. Development of preventive measures as genetic counseling, prenatal diagnosis, pre-marital screening are the best ways to decrease the incidence of disease, in addition to regular blood transfusion with optimum chelation therapy.
Citation: Ebtissam Yasseen Ali and Maysaloun Muhammed Abdulla (2022) Epidemiological and Clinical Profile of Iraqi Patients with β-Thalassemia Major, International Journal of Dentistry, Diabetes, Endocrinology and Oral Hygiene, Vol. 4, No,2, pp, 1-15
Evaluation of Cellular Immunity for Β-Thalassemia Major Patients in Wasit Thalassemia Center (Published)
The objective of this research work is to evaluation of cellular immunity for β-thalassemia major patients in Wasit Thalassemia center. Methods: hematological parameters including (Hb, WBCs), Phagocytic activity by Nitroblue Tetrazolium stain (NBT) and Enzyme linked Immuno Sorbent Assay (ELIZA) applied for estimation of the serum cytokines included IL-8, TNF-α and IFN-γ from 60 male β-thalassemia major patients and twenty healthy persons as control group. Results: the hematological parameters including Hb concentration shows significant decrease but WBCs count appeared significant increased compared with control group and significant decreased in the neutrophil activity. Interleukin-8, TNF-α and IFN-γ concentration showed significant decreased compared with control group. Conclusions: significant increase in the WBCs count and significant decrease in the Hb concentration, neutrophil activity and Interleukin-8, TNF-α and IFN-γ concentration compared with control group.
Correlation of Serum Lipid Profile with Serum Iron, Tibc & Ferritin Levels in Beta Thalassemia Major Patients (Published)
Correlation of serum lipid profile with serum iron, TIBC & ferritin levels in beta thalassemia major patients. Background- Beta thalassemia major, a common disorder, causes severe anemia. This is treated by regular blood transfusion, leading to iron overload and increased serum ferritin. There is considerable variation between studies as to the serum lipid levels in these patients. Aims- The study was carried out to observe the alteration of serum lipid levels and also whether the alteration could be correlated with ferritin and other hematological indices. Methods and materials-The study was carried out on 50 beta thalassemia major patients and 47 controls. Estimation of serum lipid profile, iron, ferritin, TIBC (Total iron binding capacity), hemoglobin and hematocrit was done. Statistical analysis-Data analysis was performed using standard methods. Results-Compared to controls, the cases had significantly higher ferritin and significantly lower HDL-C (high density lipoprotein- cholesterol) levels. There was inverse correlation between high ferritin and low HDL-C levels. Conclusion-Taken together, high ferritin and low HDL-C levels might be important predictors for mortality in thalassemia.