Evaluation of Cellular Immunity for Β-Thalassemia Major Patients in Wasit Thalassemia Center (Published)
The objective of this research work is to evaluation of cellular immunity for β-thalassemia major patients in Wasit Thalassemia center. Methods: hematological parameters including (Hb, WBCs), Phagocytic activity by Nitroblue Tetrazolium stain (NBT) and Enzyme linked Immuno Sorbent Assay (ELIZA) applied for estimation of the serum cytokines included IL-8, TNF-α and IFN-γ from 60 male β-thalassemia major patients and twenty healthy persons as control group. Results: the hematological parameters including Hb concentration shows significant decrease but WBCs count appeared significant increased compared with control group and significant decreased in the neutrophil activity. Interleukin-8, TNF-α and IFN-γ concentration showed significant decreased compared with control group. Conclusions: significant increase in the WBCs count and significant decrease in the Hb concentration, neutrophil activity and Interleukin-8, TNF-α and IFN-γ concentration compared with control group.
Correlation of Serum Lipid Profile with Serum Iron, Tibc & Ferritin Levels in Beta Thalassemia Major Patients (Published)
Correlation of serum lipid profile with serum iron, TIBC & ferritin levels in beta thalassemia major patients. Background- Beta thalassemia major, a common disorder, causes severe anemia. This is treated by regular blood transfusion, leading to iron overload and increased serum ferritin. There is considerable variation between studies as to the serum lipid levels in these patients. Aims- The study was carried out to observe the alteration of serum lipid levels and also whether the alteration could be correlated with ferritin and other hematological indices. Methods and materials-The study was carried out on 50 beta thalassemia major patients and 47 controls. Estimation of serum lipid profile, iron, ferritin, TIBC (Total iron binding capacity), hemoglobin and hematocrit was done. Statistical analysis-Data analysis was performed using standard methods. Results-Compared to controls, the cases had significantly higher ferritin and significantly lower HDL-C (high density lipoprotein- cholesterol) levels. There was inverse correlation between high ferritin and low HDL-C levels. Conclusion-Taken together, high ferritin and low HDL-C levels might be important predictors for mortality in thalassemia.