The study investigated the preparedness of pre-service science teachers towards teaching with technology. A descriptive survey research design was used for the study. A simple random sampling technique was used to draw a sample of 150 students from the population of 620 pre-service science teachers of the University of Port Harcourt. A Teaching with Technology Readiness Indicator (TWTRI) was developed by the researcher to obtain the readiness level of the pre-service science teachers. The instrument reliability was determined through test-retest method and a stability coefficient of 0.87 was obtained. Two experts in the field of Educational Technology and another two in the field of Measurement and Evaluation confirmed the validity of the instrument. Four research questions were answered with the use of mean and four corresponding hypotheses were tested using independent sample t-test. The results of the study showed that the pre-service science teachers were prepared for teaching with technologies with respect to technological skills, attitude, anxiety and self-efficacy. There was no significant difference in the preparedness of male and female pre-service science teachers. Continuous professional development, proper planning, selection of adequate technology and provision of technology infrastructure were recommended.