This paper presents both qualitative and quantitative studies on the motivation for teachers teaching in Senior High School located in rural areas and its effects on their willingness to continue staying in those areas in the Ashanti Region of Ghana. Two public Senior High Schools in the rural areas of Afigya-Kwabre West district comprising two Headmasters and 120 teachers was selected by the use of purposive and simple random sampling techniques for the study. The study focused on primary data through interview, questionnaire and observation. It was revealed that the significant retention factors are the provision and administration of financial bonuses which include retention/professional allowance and Parents and Teachers Association motivational allowance. On the other hand, the teachers were very unsatisfied with their accommodation, means of transport and criteria for selecting award winners during speech and prize giving days. Therefore, governments and policy makers need to put in place strategies and also implement policies that will serve to improve the working conditions of teachers teaching in rural areas in order to serve as motivation for their retention.