Tag Archives: Systematic Review

An Observational Analytical Molecular Neuropharmacological Research Study and a Descriptive Systematic Review on the Pharmacogenomic Mechanisms of Brain Organoids (Published)

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. Brain organoids can model congenital structural deficits or be subjected to environmental insult. This clinical research and systematic review was conducted for systematically exploring the molecular neuropharmacological and pharmacogenomic mechanisms of the brain organoids, with thorough explanations and analysis of the medical study literature and evidences compiled from the innumerous studies conducted, which explained the multi-dimensional pharmacomolecular significance of brain organoids. The objectives of this study were an observational analytical molecular neuropharmacological research study and a descriptive systematic review on the pharmacogenomic mechanisms of brain organoids.The mixed-method study was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) Statement and Guidelines, 2009, described by the Cochrane Collaboration in June, 2016. At first, the steps of identification included the records which were identified through database searching and the additional records which were identified through other sources. This led to the steps of screening, which included the screened records after the duplicates were removed. From these screened records, few records were excluded, as per the exclusion criteria. Then, in the eligibility step, the full text articles were assessed for eligibility, from which few full text articles were excluded, according to the exclusion criteria, with adequate reasons. This led to the final inclusion step, where the studies were included in the qualitative synthesis of a systematic review, according to the inclusion criteria, and ultimately the studies were included in the quantitative synthesis. An observational analytical molecular neuropharmacological research study was also conducted. In this mixed-method study, the systematic review contributed 3086 refined and relevant medical records, among total 5612 records obtained from the study databases search. It also describes the molecular neuropharmacological and pharmacogenomic mechanisms of brain organoids, which elaborated this descriptive systematic review and observational analytical molecular pharmacological research study. To conclude, this clinical research and systematic review study provided the refined qualitatively synthesised medical records, study literature and databases, as well as a descriptive analysis on the pharmacogenomic mechanisms of brain organoids.     

Keywords: Pharmacology, Systematic Review, brain organoids, molecular neuropharmacology, observational analytical clinical research., pharmacogenomics

An Observational Descriptive Analytical Research Study and a Systematic Review on the Clinical Pharmacotherapeutics of Alveolar Organoids (Published)

Stem cell-derived self-organizing three-dimensional organoids have emerged as a novel medical innovation to recapitulate respiratory diseases. This clinical research and systematic review was conducted for systematically reviewing the clinical pharmacotherapeutics of alveolar organoids, with thorough explanations and analyses of the medical study literature and evidence compiled from the different studies conducted, thus authenticating the multi-dimensional pharmacomolecular significance of alveolar organoids. The objective of this clinical research was an observational descriptive analytical research study and a systematic review on the clinical pharmacotherapeutics of alveolar organoids. The study was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) Statement and Guidelines, 2009, described by the Cochrane Collaboration in June, 2016. At first, the steps of identification included the records which were identified through database searching and the additional records which were identified through other sources. This led to the steps of screening, which included the screened records, after the duplicates were removed. From these screened records, few records were excluded, as per the exclusion criteria. Then, in the eligibility step, the full text articles were assessed for eligibility, from which few full text articles were excluded, according to the exclusion criteria, with adequate reasons. This led to the final inclusion step, where the studies were included in the qualitative synthesis of a systematic review, according to the inclusion criteria, and ultimately the studies were included in the quantitative synthesis. An observational descriptive analytical research study was also conducted on the clinical pharmacotherapeutics of alveolar organoids. This systematic review, performed in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) Statement and Guidelines, 2009, described by the Cochrane Collaboration, June, 2016, contributed 28 refined and relevant medical records, among total 37 records obtained from the study databases search. It also describes and thoroughly analyses the clinical pharmacotherapeutics of alveolar organoids which validates, clarifies, and elaborates this clinical research and systematic review.To conclude, this clinical research and systematic review provided the refined qualitatively synthesised medical records, study literature and databases on the clinical pharmacotherapeutics of alveolar organoids, with an explanatory observational descriptive analysis.  

Citation: Moumita Hazra (2022) An Observational Descriptive Analytical Research Study and a Systematic Review on the Clinical Pharmacotherapeutics of Alveolar Organoids, International Journal of Public Health, Pharmacy and Pharmacology, Vol. 7, No.2, pp.1-8

 

Keywords: Pharmacology, Systematic Review, alveolar organoids, clinical pharmacotherapeutics, clinical research, observational descriptive analysis, respiratory medicine

Systematic Review and Meta-Analysis of the Relationships between the Adequacy of Family Resources and Parenting Stress (Published)

Citation: Carl J. Dunst (2022) Systematic Review and Meta-Analysis of the Relationships between the Adequacy of Family Resources and Parenting Stress, International Journal of Health and Psychology Research, Vol.10, No.1, pp.18-30

Abstract: The birth and rearing of a child with a developmental disability or chronic medical condition is often a stressful life event for parents. Family system theory includes the tenet that the presence of family strengths, resources, and supports can buffer parents and other primary caregivers from the adverse effects of stressful life events. The aim of this systematic review and meta-analysis was the evaluate the relationships between the adequacy of family resources and three types of parenting stress (parental distress, difficult child-related stress, and dysfunctional parent-child interactions). Eleven studies including 14 independent samples of study participants met the inclusion criteria (N = 3030 parents and other primary caregivers). Ten studies were conducted in the United States and one study was conducted in South Africa between 1994 and 2018. The participants’ children had either identified disabilities (N = 8 samples) or medical diagnoses (N = 6 samples). Meta-Essentials was used to perform the systematic review and meta-analysis and included forest plot analysis, publication bias analysis, effect size aggregation, between type of parenting stress subscale comparisons, and moderator analysis. The adequacy of family resources was significantly related to less parental distress, less child-related stress, and less difficult parent-child interactional patterns. The directions of effect were the same in every study and every sample of study participants. The size of effect between the independent and dependent measures was larger for parental distress (r = -.48, 95% CI = -.51 to -.44, p < .001) compared to both child-related stress (r = -.31, 95% CI = -.42 to -.19, p < .001) and dysfunctional parent-child interactional patterns (r = -.24, 95% CI = -.29 to -.20, p < .001). There were no differences in the sizes of effect for parents of children with identified disabilities or medical diagnoses. The pattern of results is consistent with the hypothesis that the adequacy of family resources would lessen parenting stress related to the birth and rearing of a child with a developmental disability or chronic medical condition.

Keywords: Family resources, Systematic Review, family systems theory, meta-analysis, parenting stress

THE SYSTEMATIC LITERATURE REVIEW AND RESEARCHES ON DEVELOPMENT OF MICROFINANCE INDUSTRY IN INDIA (Published)

Microfinance is the array of financial services, including loans, savings and insurance, available to Poor entrepreneurs and small business owners who have no collateral and would not otherwise qualify for a standard bank loan. Recent proliferation of microfinance market has swiftly increased the competition in microfinance Indian market, new technology and new devices are emerging at phenomal speed. As the number of microfinance application is increasing at daily rate, quality is becoming major issue. So microfinance system organization need some quality model as guideline to improve and maintain quality of application under development .microfinance application mainly depends on users response and user acceptance so they need maintainability, usability, suitability etc. this research paper presents microfinance recent development model focusing on key quality characteristics. This study is applicable in the context of social development at this time when social services delivery is not only poor but at dismal level. Recent proliferation of microfinance market has swiftly increased the competition in microfinance developmental Market, new technology and new devices are emerging at phenomenal speed. As the number of microfinance applications is increasing at daily rate, quality is becoming major issue. So Microfinance industries need some quality model as guideline to improve and maintain quality of application under development. MicroFinance market mainly depends on poor people of loan response and poor people of loan acceptance so they need maintainability, usability, suitability etc. This research paper presents microfinance market quality model focusing on key quality characteristics mainly extracted from excellent standard quality model, which effect quality of microfinance market. This paper aims to provide a synthetic review of the literature on the Microfinance and development. Systematic Review of literature (SLRs) justifies the reason for our research. It demonstrates the topic. It narrates a brief elaboration of prior studies. Prior research will help us to ensure that we have included all of our major relevant constructs in our study. It talks about the knowledge of our field which allows us to identify the gap which our research could fill and also strength’s the topic that we chosen for our research. The literature review will help us to find and select appropriate measurement instruments. (P.Shakila, 2014) The literature review is needed because it is a necessary skill both for researchers and for practitioners of a profession which claims to be founded on a knowledge base and also to locate and summarize the findings of research on a given topic not uncritically but assessing the evidence and for argument to sustain the conclusions. It is also useful to obviate the need for fresh research or to replicate the study. (P.Shakila, 2014) Polit and Hungler in the year (2001) stated that the term “Literature Review” is often used to cover both the process of searching for relevant literature and the critical reporting of the literature. Cormack in the year (1991) stated that “Literature Review” means to systematically read, critically appraise, and then synthesize the material into a coherent, structured, and logical review of the literature. This paper presents a systematic review of the current use of those modern microfinance developments for the microfinance systems and their actual level. Microfinance modern recent development prediction is a significant part of microfinance quality assurance. A problem is microfinance is to expect the possibility that the microfinance contains problem. Problem in microfinance system are major problems that need to be resolved. The problem prediction in microfinance system is significant because it can help in directing test effort, reducing cost, and increasing quality of microfinance development and its reliability .in this research paper I have studied various predictions, examined, & the performance of these recent microfinance development of India. The main aim is to examine the performance of recent development of microfinance in microfinance a problem prediction. Problem prediction using these techniques helps in improving the quality of the microfinance recent development

Keywords: Development, Development Quality, Economic Development, Economic Development Attitude, Entrepreneurship Development, Evaluation and effectiveness of Microfinance, India Economy, Microfinance Institutions, Microfinance and Development, Satisfaction of Access & Rights to Justice of Poor People, Systematic Literature Review, Systematic Review

TRAINING OF PATHOLOGY LABORATORY TECHNICIANS-A SYSTEMATIC REVIEW (Published)

The purpose of this paper is to present a systematic review of the training of technicians in pathology laboratories, as well as the current level of pathology technicians in the world. This paper follows the structure of the PRISMA model with slight modifications. The findings of the review indicate that recent developments such as increased application of molecular biology in pathology, ICT advancement, increased need for quality assurance, and the emergence of other important skills are some of the key factors influencing changes in the required skills and competencies for pathology technicians. These required skills and competencies are similar in all countries. However, there is a lower availability of skilled and competent pathology technicians than is needed. Among other impacts, this issue has contributed to an increased number of errors in pathology laboratories during recent years, and to the inability to implement new technology in the laboratories

Keywords: Laboratories, Pathology, Systematic Review, Training