Tag Archives: SCC

The Expression of Interlukin 2(Il- 2), Interlukin 8(Il-8) and Interlukin 6(Il-6) In Patients with Oral and Oropharyngeal Squamous Cell Carcinoma in Basrah City (A Case Control Study) (Published)

The first part of the digestive tract is the oral mucosa, which exposed to different exogenous toxins ,long period of  exposure could lead to malignant changes /tumors. One of the prevalent cancers of the body is Oral squamous cell carcinoma, oral cancer sometimes may be resemble   benign lesions in the mouth therefor, the diagnosis may be not easy clinically. There appear the  importance of serum cytokines in distinguishing different pathologies. Aims :The aim of this study was to identify the role  of  serum Interlukins (IL2  ,IL6, IL8 ) in  the early  detection  and pathogenesis  of oral and oropharyngeal  squamous cell carcinoma. Patients and Methods: This study included 20 patients with oral and oropharyngeal squamous cell carcinoma were clinically diagnosed and then confirmed by histopathological  examination and 26 healthy control  . Age, gender, as well as the level of interlukins in the serum of patients  and healthy control were measured,in addition  clinical signs and the site of lesions were recorded for patients group. Results: There were 20  new cases of oral   and oropharyngeal  squamous cell carcinoma in Basrah from  September 2015 to December  2016   , 12 in men and 8  in women . 26  healthy control individuals  17 men and 9 female were included in this study . Cancer at all oral sites affected men more than women. The Tongue  is the most frequent site .The level of  serum Interlukins (IL2, IL6, IL8) in  patients group were much more  than those in healthy control group

Keywords: Inflammation, Interlukins, Oral, Oropharyngeal Squamous Cell Carcinoma, SCC