Tag Archives: Pharmacology

An Observational Analytical Molecular Neuropharmacological Research Study and a Descriptive Systematic Review on the Pharmacogenomic Mechanisms of Brain Organoids (Published)

Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. Brain organoids can model congenital structural deficits or be subjected to environmental insult. This clinical research and systematic review was conducted for systematically exploring the molecular neuropharmacological and pharmacogenomic mechanisms of the brain organoids, with thorough explanations and analysis of the medical study literature and evidences compiled from the innumerous studies conducted, which explained the multi-dimensional pharmacomolecular significance of brain organoids. The objectives of this study were an observational analytical molecular neuropharmacological research study and a descriptive systematic review on the pharmacogenomic mechanisms of brain organoids.The mixed-method study was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) Statement and Guidelines, 2009, described by the Cochrane Collaboration in June, 2016. At first, the steps of identification included the records which were identified through database searching and the additional records which were identified through other sources. This led to the steps of screening, which included the screened records after the duplicates were removed. From these screened records, few records were excluded, as per the exclusion criteria. Then, in the eligibility step, the full text articles were assessed for eligibility, from which few full text articles were excluded, according to the exclusion criteria, with adequate reasons. This led to the final inclusion step, where the studies were included in the qualitative synthesis of a systematic review, according to the inclusion criteria, and ultimately the studies were included in the quantitative synthesis. An observational analytical molecular neuropharmacological research study was also conducted. In this mixed-method study, the systematic review contributed 3086 refined and relevant medical records, among total 5612 records obtained from the study databases search. It also describes the molecular neuropharmacological and pharmacogenomic mechanisms of brain organoids, which elaborated this descriptive systematic review and observational analytical molecular pharmacological research study. To conclude, this clinical research and systematic review study provided the refined qualitatively synthesised medical records, study literature and databases, as well as a descriptive analysis on the pharmacogenomic mechanisms of brain organoids.     

Keywords: Pharmacology, Systematic Review, brain organoids, molecular neuropharmacology, observational analytical clinical research., pharmacogenomics

An Observational Descriptive Analytical Research Study and a Systematic Review on the Clinical Pharmacotherapeutics of Alveolar Organoids (Published)

Stem cell-derived self-organizing three-dimensional organoids have emerged as a novel medical innovation to recapitulate respiratory diseases. This clinical research and systematic review was conducted for systematically reviewing the clinical pharmacotherapeutics of alveolar organoids, with thorough explanations and analyses of the medical study literature and evidence compiled from the different studies conducted, thus authenticating the multi-dimensional pharmacomolecular significance of alveolar organoids. The objective of this clinical research was an observational descriptive analytical research study and a systematic review on the clinical pharmacotherapeutics of alveolar organoids. The study was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) Statement and Guidelines, 2009, described by the Cochrane Collaboration in June, 2016. At first, the steps of identification included the records which were identified through database searching and the additional records which were identified through other sources. This led to the steps of screening, which included the screened records, after the duplicates were removed. From these screened records, few records were excluded, as per the exclusion criteria. Then, in the eligibility step, the full text articles were assessed for eligibility, from which few full text articles were excluded, according to the exclusion criteria, with adequate reasons. This led to the final inclusion step, where the studies were included in the qualitative synthesis of a systematic review, according to the inclusion criteria, and ultimately the studies were included in the quantitative synthesis. An observational descriptive analytical research study was also conducted on the clinical pharmacotherapeutics of alveolar organoids. This systematic review, performed in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) Statement and Guidelines, 2009, described by the Cochrane Collaboration, June, 2016, contributed 28 refined and relevant medical records, among total 37 records obtained from the study databases search. It also describes and thoroughly analyses the clinical pharmacotherapeutics of alveolar organoids which validates, clarifies, and elaborates this clinical research and systematic review.To conclude, this clinical research and systematic review provided the refined qualitatively synthesised medical records, study literature and databases on the clinical pharmacotherapeutics of alveolar organoids, with an explanatory observational descriptive analysis.  

Citation: Moumita Hazra (2022) An Observational Descriptive Analytical Research Study and a Systematic Review on the Clinical Pharmacotherapeutics of Alveolar Organoids, International Journal of Public Health, Pharmacy and Pharmacology, Vol. 7, No.2, pp.1-8

 

Keywords: Pharmacology, Systematic Review, alveolar organoids, clinical pharmacotherapeutics, clinical research, observational descriptive analysis, respiratory medicine

Catalogue of the Medicinal Plants Used In the Treatment of Urinary Infections in the Area of Al-Haouz Rhamna (Central Morocco) (Published)

In the framework of the ethnobotanical studies on medicinal plants used in traditional medicine in the treatment of urinary infections(pyelonephritis, cystitis and urethritis) and to better knowledge of these plants, we are interested in the area of Al Haouz-Rhamna (central Morocco) which presents a rather important floristic richness due to varied climatic and ecological factors. The ethnobotanical surveys, based on 1700 interviews, were conducted during two periods in 2012 and 2013, among actors of the traditional medicine and the population of this region. This study led to identify and establish a catalog of 135 plant species are distributed between 106 genera and 50 families, with important predominance: Lamiaceae, Apiaceae, Asteraceae and Fabacea. A total of 135 plants, 35 species were reported as the most efficient plants against urinary tract infections and 30 species were shown to be toxic. En the more, it is important to note that the majority of users of medicinal plants have limited knowledge in the field of traditional medicines and are unable to distinguish between the following urinary tract infections: pyelonephritis, cystitis and urethritis. Similarly, the majority of the recipes used in the treatment of urinary tract infections is presented in association with two or more species and are prepared as decoction (55.81%) from different parts of medicinal plants. The information reported by this study could be a very valuable source of information for the study area and may also be a synthetic approach that can form the basis for phytochemists and pharmacologists interested in research on plants used in the treatment of urinary tract infections and as a base for future generations.

Keywords: Al Haouz-Rehamna, Pharmacology, Phytotherapy, Toxicity, Traditional Medicine, Urinary Infections.