This research works focuses on infertility as a factor that led to marriage break up, which stem from primordial sentiments to technological advancement. For a marriage to be stable, reproduction by giving birth to offspring play crucial role. The fertility factor is important consideration in marriage stability. It then follows that fertility is important as any other relationship in marriage stability. Generally, the evaluation of the effect of infertility on marital instability have centred on divorce in case of the woman or polygamous (marry another wife) in case of the man,fagbohungbe, (2001). This fact reflects a lack of proper understanding of infertility and marital instability. The effects of infertility on marital instability manifest in many capacities. Among these: lack of affection and love, lack of trust, extra marital affairs, depression and emotional problems. It is therefore necessary to empirically study how these factors contribute to the challenges of infertility and marital instability, consequently, the study also examine the influence of religion, educational level and socio- economic status of the couple on infertility and its effect on marital instability.