In recent times, ardent watchers and analysts of the Nigerian project have suggested that the country has endemic leadership issues with genetic foundations deeply rooted in Her DNA. Although this assertion has been sharply contested, the apparent malady in the current behaviours of persons in key leadership positions in the country seems to have assumed worrisome dimensions .The observed leadership behaviours have taken an impoverishing toll on the efforts at National Development. Thus, this work, in the bid to evolve persons with development –centric leadership behaviours, took an organic approach to attempt to resolve the underlying leadership malaise. This was done using metaphoric symbolisms and biological analogies to have an introspective view of aspects of molecular ecology. This dimension was adopted in order to explain how leadership behaviour mutation could counteract the prevailing leadership trend and provide actionable thoughts for the ultimate attainment of sustainable National Development.