Long before the era of high through-put screening and genomics, drug discovery relied heavily on natural products. Drug discovery involves the identification of New Chemical Entities (NCEs) of potential therapeutic value, which can be obtained through isolation from natural sources, through chemical synthesis or a combination of both. However, the success stories for the discoveries Penicillin from penecilium rubens, Paclitaxel yew tree and marketed as Taxol, Aspirin from Willow bark of Salix alba tree etc. have pave way for scholars in the field of natural product and organic chemistry to focus their research work in drug-derived from plants and microorganisms. Natural products derived from these sources are rich in bioactive compound, which have been use over years throughout human history and evolution as remedies for various ailments. This paper however, X-rayed the sources and classes of natural products, pharmaceuticals derived from Natural product, and uses of natural products. The paper also recommended among others that, government should fund research in the area of natural products, pharmaceutical chemistry and pharmacognocy.
In this study, the screening of plastic degrading microbes was done by using opaque method separately for bacteria and fungi. Four bacterial species and two fungal species which formed most opaque were used for further studies. The bacterial species was identified as Bacillus amylolyticus, Bacillus firmus, Pseudomonas putida, Pseudomonas fluroscence. Their effectiveness on the degradation of commercial polythene carry bags of Low Density Polyethylene was studied over a period of 30 days in shaker culture under laboratory conditions by weight determination method and it was found that Bacillus sp. isolated from Garbage soil degrades the plastic up to 32%. This work reveals that Bacillus amylolyticus posses greater potential to degrade plastics when compared with other bacteria.
The aims of this paper were to study the biofouling and biodeterioration of books stored at the Archive of the library of Shumen University, Bulgaria, and to carry out the physiological characterization of isolated fungi and bacteria. Also the role of the environmental microbiota in the biofouling formation was studied. Microbial assemblages on documents were sampled by sedimentation method as described by Omeliansky. Biofouling were monitored by microscope and stereomicroscope OPTIKA (Italy). Large microbial assemblages were found at archive with the prevalence of genera Aspergillus, Cladosporium and Penicillium. Most of the fungi degraded cellulose and produced pigments and acids, and all of the isolated bacteria had proteolytic and/or cellulolytic activity. In shed a higher concentration of viable bacteria than of fungi was isolated. The existence of this bacterial genus in the Library of Shumen University indicates that the faulty ventilation system needs to be repaired and suitable anti-dust filters to be set.