Tag Archives: Liver Enzymes

The role of panax ginseng plant and vitamin D in improving the effectiveness of liver enzymes ALT, AST and ALP in rabbits exposed to X-rays. (Published)

This study was conducted at Animal House, Faculty of Veterinary Medicine\ University of Tikrit , The dosage period was from the beginning of January for (10) days. This study was designed to investigate the protective role of ginseng root and vitamin D3 in animals irradiated by X-ray in rabbits. 50 domestic animals were used from local rabbits Lepus cuniculua domestica Which was obtained from the veterinary hospital at the Ministry of Agriculture – Samarra Agriculture Department, Ranging between 7-9 months and their weights (1250 – 1500 g), The animals were randomly assigned to (10) groups, and each group (5) animals. The (Control) group was the control group where the diet was given with regular drinking water, the Second Group (A): treated with X-ray for one day only, The Third group (B): was treated X-ray and ginseng (150 mg/kg) for one day only, The Fourth group (C) was treated X-ray and ginseng (300 mg/kg) for one day only, The Fifth group (D): was treated X-ray and vitamin D3 (30 IU/kg) for two days only, the Sixth Group (E): X-ray and ginseng (150 mg/kg) and vitamin D3 (30 IU/kg) for only two days, The Seventh group (F): treated X-ray for only two days and left for only 10 days, the Eighth Group (G): was treated X-ray and ginseng (150 mg/kg) for two days and left for only 10 days, The Ninth group (H): was treated X-ray and vitamin D3 (30 IU/kg) for two days and left for 10 days, and the Tenth group (I): was treated X-ray, ginseng (150 mg/kg) and vitamin D3 (30 IU/kg) for two days and left for 10 days.The results of the study showed an increase in the effectiveness of liver enzymes ALP, AST, ALT in X-ray exposed group compared to control group sound. As well as a significant decrease in most studied groups and variance in other groups compared to the group exposed to X-ray.We deduce the obvious effects on the enzymes and hormones of the body as a result of x-ray exposure and increase the oxidative stress on the surface of the cells and the effective protective role of ginseng root and vitamin D3 as effective antioxidants and reduce the damage caused by radiation.

Keywords: Liver Enzymes, Panax gensing, Vitamin D

Serum Liver Enzymes as Markers in Assessing Physiologic Tolerance of Amalar, Cotecxin, Chloroquine and Fansidar (Published)

Colorimetric assay was used in the determination of plasma concentrations of aspartate amino transferase (AST), alanine amino transferease (ALT) and alkaline phosphate (ALP) in the administration of amalar, chloroquine, cotecxin and fansidar. In amalar group the aspartate amino transferase (AST) and alanine amino transferase (ALT) significantly decreased against control, (P<0.05) but there was no significant diference in the decrease of alkaline phosphatase (ALP) (P<0.05) when compared with control. In the chloroquine group there was increase in aspartate amino transferase (AST) and a decrease in alanine amino transferase (ALT) significantly (P>0.05) but the decrease in alkaline phosphatase (ALP) was not significant when compared with control (P<0.05). There was no significant difference in the concentrations of aspartate amino transferase (AST) and alkaline phosphatase (ALP) (P>0.05) in cotecxin group when compared with control but the decrease in alanine amino transferase (ALT) was significant (P<0.05). In fansidar group there was no significant decrease in aspartate amino transferase (AST) (P>0.05) but alanine amino transferase (ALT) showed significant decrease (P<0.05), whereas the alkaline phosphatase decrease (ALP) was not significant (P>0.05) when compared with control. It is observed in this study that chloroquine has damaging effect on the liver by elevating alanine and aspartate amino transferase respectively whereas fansidar lowers the activities of the liver by decreasing alanine amino transferase. It means that chloroquine and fansidar administration endangers liver functions via its enzyme systems dysfunctioning.

Keywords: Antimalarials, Liver Enzymes, Physiologic Tolerance