Sergio Leone in the classical 1966 film ‘the Good, the Bad and the Ugly’ (Il buono, ilbrutto, il cattivo) produced by Alberto Grimaldi depicts the theme of ‘violence and a deconstruction of Old west Romanticism. As in the title which makes a juxtaposition of varying themes inherent in one movie, science has over the years become potent for both the good and the bad. With its mind-blowing breakthroughs, it has unlocked mysteries, created new knowledge. It has equally generated anxieties and dominance via its methodological rules. This paper examines science and her envisioned biotechnological inventions from the prism of imperialism anchored on methodology. Employing philosophical analysis as our underlining method, we argue for caution against this scientific incursion.