Evaluation of Cellular Immunity for Β-Thalassemia Major Patients in Wasit Thalassemia Center (Published)
The objective of this research work is to evaluation of cellular immunity for β-thalassemia major patients in Wasit Thalassemia center. Methods: hematological parameters including (Hb, WBCs), Phagocytic activity by Nitroblue Tetrazolium stain (NBT) and Enzyme linked Immuno Sorbent Assay (ELIZA) applied for estimation of the serum cytokines included IL-8, TNF-α and IFN-γ from 60 male β-thalassemia major patients and twenty healthy persons as control group. Results: the hematological parameters including Hb concentration shows significant decrease but WBCs count appeared significant increased compared with control group and significant decreased in the neutrophil activity. Interleukin-8, TNF-α and IFN-γ concentration showed significant decreased compared with control group. Conclusions: significant increase in the WBCs count and significant decrease in the Hb concentration, neutrophil activity and Interleukin-8, TNF-α and IFN-γ concentration compared with control group.
THE PREVALENCE OF SOIL TRANSMITTED HELMINTHES AMONG SCHOOL CHILDREN IN IFEDORE LOCAL GOVERNMENT AREA OF ONDO STATE, NIGERIA (Published)
The current status of intestinal helminthes was assessed among schools children in Ifedore Local Government of Ondo State, Nigeria. A total of 180 faecal samples were collected randomly from each of the primary schools sampled. Detection and identification were by direct microscopy. Questionnaires were administered to identify the major activities and behaviour of pupils, their knowledge about the aetiology and control of intestinal helminthes.
Chi- square was used to determine if there was any relationship between age and sex on the occurrence of the helminthes. Of the 180 pupils examined, 88 (48.9%l) were infected. Three parasite species observed were Ascaris lumbricoides (22.2%), Strongyloides stercoralis (12.8%), Hookworm (10.6%) and for multiple infection (3.3%). Females had higher prevalence (25.6%) than males (23.3%). No significant association was observed among worm infectivity, age and sex in the population studied. The study revealed that poor hygienic practices and unsanitary condition were responsible for the high prevalence of these helminthes. Health Education through primary health care could be used as a control measure
Evaluation Of Beniseed Extract and Fermented Liquor in Treatment of Diarrhoea in Albino Rats Infected with Salmonella Typhi (Published)
The efficacy of fermented beniseed liquor and the methanol extract in treating diarrhoea caused by Salmonella typhi in albino rats orogastrically infected with the bacteria was assessed. At the end of the experiment, haematological, biochemical and liver functioning tests were performed on the blood from the animals. The results obtained from this analysis showed that the selected organism have high infectivity dose, caused a significant reducing effect on the weight of the albino rats and negative effect on the hematological and biochemical parameters assessed. Treatment of infected animals with the fermented liquor and methanol extract of beniseeds showed that both caused a significantly quick recovery of the infected animals from diarrhoea within five days of treatment. However, the rate of recovery was faster with the group of infected rats treated with the fermented beniseed liquor than the extract. Also, treatment with methanol extract of beniseeds also caused a significant increase in the cholesterol level of the blood from the animals. The results obtained from these analyses showed that beniseed have therapeutic properties and that the fermented form is more effective and can be used to treat diarrhoea caused by the selected bacteria used in this study in albino rats.