Science and technology has made a remarkable impact in the development of many nations’ economy in this 21st century. The application of scientific knowledge in production has made tremendous development of infrastructures. Technology has elevated the economy of many nations through the introduction of modern technology that brought comfort and stability in man’s life. The foundation of technology is science; it is justifiable to say that science is the power of technology. The application of scientific knowledge has helped man to produce modern infrastructures and amplified the development of many nations. This study is focused on comparing the impact of science and technology in the developing nations. Questionnaire was the main instrument used for data collection. Data collected were analysed using descriptive statistics to find the mean difference of science and technology. Findings and recommendations were made based on analysis of data.