Chronic Hyperglycemia and Biochemical Alterations Induced Hepatic-Renal Dysfunction in Rats Administered Ethylacetate Fraction of Plumbago Zeylanica, Linn (Published)
Chronic hyperglycemia is an independent predictor of death in myocardial infarctions and nephropathy and it is a major cause of organ damage. Previous studies have shown that administration of Plumbago zeylanica extract elevated significantly the glucose concentration of the organism even though there have been many claims of the ameliorative effects of the plant. Hence, we investigated the likely dysfunctions of liver and kidney that may results from the induced hyperglycemia. Twenty rats (150-190 g) were grouped into four of five rats per group. Group 1 (control) was administered 2% Tween-20 and groups 2, 3 and 4 were administered 100, 200 and 400 mg/kg b. wt. doses of P. zeylanica ethylacetate (PZE) fraction respectively. Administration of PZE for 28 days significantly increased the plasma glucose level suggesting hyperglycemia. The activities of plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were significantly increased thereby suggesting hepatic dysfunction and the kidney function monitored by plasma protein, creatinine and urea levels was impaired by PZE suggesting renal dysfunction. However, there was no significant change in the level of lipid profile. PZE elicited hyperglycemic effect, hepatic and renal dysfunctions in a dose-dependent manner. Thus, the inducement of hyperglycemia by PZE may have resulted into organ damage noticed in the liver and kidney. Therefore, PZE should be used as herbal medicine with caution.