Tag Archives: Gastrointestinal tract

Histological Effects of Aqueous Stem Bark Extract of Cadaba farinosa on the Gastrointestinal Tract of Adult Wistar Rats (Published)

In a global context and developing countries Nigeria inclusive, herbal medicines are major source of healt:hcare. Among plants widely used as therapeutic agents for treating various forms of cancer is Cadaba farinosa. However, there are limited published reports about the possible therapeutic effects of this plant especially on the gastrointestinal tract. The aim of this study is to evaluate the effects of aqueous stem bark extract of Cadaba farinosa on the gastrointestinal tract of adult Wistar rats.Thirty adult rats of both sexes were used and divided into five groups of six rats each. Group 1 served as control. Aqueous extracts were administered to study groups (2, 3, 4 and 5) at different doses of 100, 200, 300 and 400 mg/kg respectively. Haematological parameters such as RBC count and RBC indices (Hgb, MCV, MCH and MCHC) determined after 28 days (sub-chronic) using standard techniques. Histology of gastrointestinal tract was examined at highest dose of 400mg/kg.  This study showed that acute oral administration of aqueous stem bark extract of Cadaba farinosa is relatively safe up to 5000mg/kg body weight/day. Histological findings showed normal sections of gastrointestinal tract among study groups. However, there are increased goblet cells proliferations and secretions in animals treated with various doses of extract. The haematological parameters were within normal limits.Aqueous stem bark extract of Cadaba farinosa in animal models ameliorates gastrointestinal mucosal damage resulting from reduced mucosal barrier from mucus secretion (anti peptic ulcer).

Keywords: Cadaba farinosa, Gastrointestinal tract, Wistar rats, ulcer

Protective Effects of Aqueous Leaf Extract of Cadaba Farinosa on Histology of the Gastrointestinal Tract of Adult Wistar Rats (Published)

Protective effects of phytochemicals offer notable prospects in exploring new therapeutics. Herbs are effective treatments of Peptic ulcer diseases than synthetic drugs. Most synthetic drugs cause adverse effects including impotence and hematopoietic disorders on chronic usage. Current treatments mainly targets potentiation defensive system of gastrointestinal tract with lowering acid secretion. Cadaba farinosa is a flowering plant in the Capparidecae family with high ethno-medicinal value, referred as ‘mucosae plant medicine’. Traditionally, it’s used for treatments of diarrhoea, dysentery and intestinal helminthes. This study investigated cytoprotective effects of oral administration of aqueous leaf extracts. Sixteen adult Wistar rats were divided into four groups of four rats. Group 1 is control. Extract administered to groups (2, 3 and 4) at 100, 200 and 300 mg/kg, showed increased goblet cells secreting mucus; a major lining epithelia vulnerable to cellular compartment. Hence, phytochemicals offers notable prospect for exploring new therapeutics.

Keywords: Cadaba farinosa, Epithelia, Gastrointestinal tract, Goblet cells, Leaf, Mucus