Effect of Cassava (Manihot Esculenta, Crantz) Extract on Biochemical Profile of Infected Albino Rats (Published)
This study is designed to evaluate the effect of ethanolic extract of Cassava (Manihot esculenta, crantz) on biochemical profile of Albino Rats. Four varieties of cassava leaves were used: two for sweet cassava (TMS 98/0505, TME 419) and two for bitter cassava (TMS 98/0002, NR 8082). Eighty Wistar Albino Rats of both sexes weighing 150-200g were used. The animals were orally infected with human intestinal parasites. They were randomly divided into 5 groups and subjected to different treatments. The results showed that sweet cassava varieties caused significant decrease (P<0.05) in the valves of ALT, ALP and CRT, while bitter cassava varieties caused significant increase (P<0.05) in the levels of ALT, ALP and CRT in the treated groups when compared with control. The ethanolic extract of the Sweet Cassava Varieties protected the liver and kidney of Albino Rats from damage caused by intestinal parasitic infections. These Varieties are useful phytomedicines for controlling intestinal parasite infections.
THE EFFECT OF ETHANOLIC EXTRACT OF BRYOPHYLLUM PINNATUM ON THE MICRO ANATOMY OF THE TESTES OF ADULT MALES WISTER RATS (Published)
The main aim of this research study is to determine the effect of ethanolic fractions of bryophyllum pinnatum leaves on the male testes using adult male wistar rats. Thirty (30) adult male wistar rats were divided into three groups of ten rats each. Group (A) serve as the control group and was administered with distilled water, Group (B) was treated with 100mg/kg/body weight of the bryophyllum pinnatum extract. Group (C) received 200mg/kgbw of the extract. The treatment lasted for a duration of 8weeks. The rats were sacrificed the day after the last dose and the testes were removed and processed for histological studies. The results from the treated groups showed increase intercellular spaces within the seminiferous epithelium, shrunken and increase lumen, suggesting cells disintegration. This is indicative that bryophyllum pinnatum extract may have adverse effect on the testes of the treated rats