The main objective of this study is examines the effect of Nigerian elite’ overseas medical treatment on the economy of Nigeria. Both quantitative and qualitative data collected through informal interview and structured questionnaire administered to a sample of 102 Nigerian elites across the thirty six states of Nigeria. The data were analyzes using, mean average and multiple regression analysis. The result shows that Nigerian elite’ overseas medical treatment has negative and statistically significant effects on the Nigerian economy. More so, Nigerian elite’ overseas medical treatment have effect on the capital flight and unemployment. Based on this findings it is therefore recommended that Nigeria governments and stakeholders in health sector at all level should formulate appropriate policy that will discourage Nigerian elite overseas medical treatment by provide necessary world class medical infrastructures with best medical team that are well qualify to managed this medical institution. Furthermore, provision of quality of healthcare delivery in the country; restore the confidence of Nigerian elites in the health sector, and, more importantly, create the enabling environment for the nation’s brains in the Diaspora to return home and boost our medical tourism.