The study investigated teachers’ instructional practices in senior high schools at Bantama in the Kumasi metropolis. The objectives of the study were to identify instructional practices mostly used, established whether significant association exist between number of years taught and instructional practices, assess whether significant difference exist between gender and teachers’ instructional practices. One research question and two hypotheses were formulated to direct the study. Descriptive survey design was adopted for the study. The schools and teachers were chosen using purposive sampling technique. Ninety-six teachers constituted the sample size for the study. Questionnaire was the main data gathering instrument used for the study. Pre-test conducted yielded reliability coefficientof 0.82. Data were analyzed using means and standard deviations, Pearson Chi-Square (x2) of Independence and Independent Sample T-test. Findings indicated that teachers mostly studied the performance of students. Significant and positive association was established between teachers’ instructional practices and number of years taught. It was therefore, recommended among others that there is a continuous need for teachers to reinforce the practice of studying performance of students to enable them modify methods of teaching to benefit all manner of students. Ghana Education Service needs to organise workshop on effective instructional practices every academic year for teachers to update their knowledge on instructional practices they ought to apply.