Long before the era of high through-put screening and genomics, drug discovery relied heavily on natural products. Drug discovery involves the identification of New Chemical Entities (NCEs) of potential therapeutic value, which can be obtained through isolation from natural sources, through chemical synthesis or a combination of both. However, the success stories for the discoveries Penicillin from penecilium rubens, Paclitaxel yew tree and marketed as Taxol, Aspirin from Willow bark of Salix alba tree etc. have pave way for scholars in the field of natural product and organic chemistry to focus their research work in drug-derived from plants and microorganisms. Natural products derived from these sources are rich in bioactive compound, which have been use over years throughout human history and evolution as remedies for various ailments. This paper however, X-rayed the sources and classes of natural products, pharmaceuticals derived from Natural product, and uses of natural products. The paper also recommended among others that, government should fund research in the area of natural products, pharmaceutical chemistry and pharmacognocy.
Assessment of Knowledge of Drug and Dietary Regimen among Diabetic Client in Endocrinology Clinic at Federal Medical Centre Ido-Ekiti, Ekiti State Nigeria (Published)
The study focused on assessment of knowledge base on dietary and drug regimen in diabetes mellitus management among patients attending Endocrinology Clinic at Federal Teaching Hospital, Ido-Ekiti in Ekiti State, Nigeria. It identified factors associated with poor adherence/compliance to treatment and relationship between demographic data and knowledge of drug and dietary regimen. Cross-sectional descriptive design was employed using a semi structured interviewer administered questionnaire to gather information from 120 clients. Simple random sampling technique (balloting type) was used to select clients. Data analysis was done using SPSS version 20 and hypotheses tested using Chi-Square, while P value was set at <0.05. The results of the study showed that majority of the respondents were above age 40. The knowledge of clients on dietary and drug regimen was on the average (50% & 45.8% respectively). Factors that affected adherence to drug treatment were high cost of antidiabetic drugs and the idea of taking drugs for life. There was a significant relationship between gender and knowledge of drug but no significant relationship between gender and knowledge of dietary regimen. Conclusion was that clients had average knowledge of drug and diet regimen and high cost of drugs affected compliance/adherence. Therefore Nigerian government should subsidize antidiabetic agents, while nurses and other medical personnel should educate clients on treatment regimen.
A linguistic analysis of selected antibiotic information leaflets examined the language structures in composing the information of both manufacturing and marketing drug companies in Nigeria. These companies on which their leaflets are studied are Emzor, Jawa, Cika, Transglobe and Taylek. A descriptive design was adopted for the study and the models of Crystal and Davy (1985) and Leech and Short (1981) were used toanalyse the pattern of interlocking grammatical systems, from the smallest units of words and phrases to larger unit of sentences. The study examined and analysed syntactic structures in the formation of linguistic sentences used on the information leaflets, which varied in different sentence types that provide meaningful explanation about the chemical compositions of the produced drugs. Relatively, it determined the sense relations of the connected sentences and the graphological features contained on the leaflets. Conclusively, it was stated that the language used in the construction of sentence is complex in nature due to over use of chemical terms. It was recommended that leaflets should be written in simple sentence devoid of complexity for drug user’s comprehension.
Drug addiction is a complex illness. It is characterized by intense and, at times, uncontrollable drug craving, along with compulsive drug seeking and use that persist even in the face of devastating consequences. Counsellors therefore need to study and develop multi-faceted drug intervention models that are “drug specific” to the addiction at hand. One size does not fit all. This paper looks at the various approaches to rehabilitation used to enhance recovery of alcoholics and drug abusers in registered inpatient rehabilitation centres in Kenya. A descriptive study that used a qualitative approach was carried out. The study focused on all the residential drug rehabilitation centres in and around Nairobi. The Study Sample included the counselors directly dealing with the treatment of clients in these centres. A two level questionnaire was used to establish the treatment models used in the various in patient drug rehabilitation centres from the respondents, using a qualitative key informant interview. Data was analysed and presented using descriptive and inferential statistics. The study found out that various models of treatment were used for treatment of clients admitted in drug rehabilitation centres in Nairobi. The commonly used models included the 12 step program of the Minnesota model, Therapeutic community model, Medical model and in most places a mixture of the various models.
The study investigated adolescence drug abuse among university undergraduates in university of Benin Edo State of Nigeria. The design used for the study was the survey. A sample of 200 students was randomly selected form five faculties which were made up of 100 male and 100 female. A validated instrument, Drug Habit Inventory (DHI, Fayombo, 1998) was used to collect relevant data. The data collected was analyzed using a t-test descriptive statistic. The findings show a significant difference between the adolescence drug abuser and non-drug abuser and also there was a difference between the male abuser and female abuser but there was no statistical significant difference between the academic performance of adolescence drug abuser and non-drug abuser. Based on the findings, recommendations were made on how to reduce drug abuse among the university undergraduate.