Tag Archives: Distributions

Age-Related Changes IN Concentration and Histological Distribution of Br, Ca, Cl, K, Mg, Mn, and Na in Nonhyperplastic Prostate of Adults (Published)

The variation with age of the Br, Ca, Cl, K, Mg, Mn, and Na concentration in prostatic parenchyma and the relationship of these chemical elements with basic histological structures of nonhyperplastic prostate glands of 65 subjects aged 21–87 years was investigated by an instrumental neutron activation analysis and a quantitative morphometric analysis. Mean values ± standard error of the mean (M±SΕΜ) for the concentrations (mg/L) of these trace elements were: Br 7.07±0.75, Ca 442±27, Cl 2688±142, K 2455±94, Mg 236±15, Sr 0.285±0.015, and Na 2238±73.  A significant trend for decrease with age in Mn concentration as well as for increase with age in relative volume of stroma and decrease in relative volume of epithelium was found.  It was demonstrated that the glandular lumen is a main pool of Ca accumulation in the normal human prostate, for the age range 21 to 40 years. For ages above 40 years a significant direct correlation between the prostatic K concentration and per cent volume of the stroma as well as a significant inverse correlation between the prostatic K concentration and per cent volume of the lumen was seen. Thus, for ages above 40 years conclusive evidence of a disturbance in prostatic chemical element concentrations and their histological distribution was shown.

Keywords: Adult, Chemical Element, Distributions, Geriatric, Histological Structures, Neutron Activation Analysis., Prostate Glands, Relationships