Hepatoprotective Activity of Aqueous and Methanolic Extracts of Watermelon Seeds On Salt and Paracetamol-Induced Liver Damage in Female White Rats (Published)
Paracetamol is the commonest over the counter drug for the treatment of body pains. However, an overdose of this drug has detrimental effects on the liver and other internal organs such as the kidneys. This experiment was conducted to investigate the hepatoprotective and regenerative effects of aqueous and methanolic extracts of watermelon seeds on the liver of rats given overdose of common salt and paracetamol. Thirty five (35) female albino rats were used for this experiment and the rats were randomly distributed into seven groups with each group containing five (5) rats. The rats in group A were given only vital feed (40% of the body weights of the rats) without any extract. This was the normal group. The rats in groups B, D and E were given physiological saline at the dosage of 10g/kg body weight once orally. In addition, 200 mg/kg and 400 mg/kg (body weight) of aqueous extract of watermelon seed were given to rats in groups D and E orally twice daily respectively. The rats in groups C, F and G were given paracetamol at dosage of 3g/kg body weight once orally at the beginning of the experiment. In addition, 200 mg/kg and 400 mg/kg (body weight) of methanolic extracts of watermelon were given to rats in groups F and G orally twice daily respectively. These experiments were monitored for 28 days. The results of the histopathological analyses showed that overdose of salt and paracetamol damaged the liver cells of the rats. However, treatments of the rats with aqueous and methanolic extracts of the seeds of watermelon have hepatoprotective and regenerative properties.
Optimization of Screw Press Extraction of Citrillus Lanatus Seed Oil and Physicochemical Characterization (Published)
The aim of this study was to optimize the extraction of C. lanatus seed oil using a screw press. Response surface methodology (RSM) was employed to describe the effects of pressing temperature and restriction diameter on oil yield and residual oil content using a Doehlert design. The seed oil extracted was characterized to determine its quality. Results showed that the experimental data were adequately fitted into the second-order polynomial model. The pressing temperature and restriction diameter had a significant effect on the screw press performance. The optimum conditions within the experimental domain were the pressing temperature of 92 °C and restriction diameter close to 4 mm. Under these conditions, the oil yield was 38.79%. The colour of clarified oil was light yellow. Its physical and chemical properties come up to the required standard for edible oil. Therefore, C. lanatus seed oil extracted by screw press could have important applications in human nutrition
Investigation of the Corrosion Inhibition of Mild Steel in Acidic Medium by Extract from Citrullus Lanatus Rind (Published)
Corrosion Inhibition of mild steel in acidic medium by ethanol extract of citrullus lanatus plant has been studied using weight loss method. The result of the study revealed that different concentrations of the extract of citrullus lanatus inhibited mild steel corrosion in 0.2M concentration of hydrogen tetraoxosulphate VI solution. The inhibition ability of the rind extract is attributed to the presence of the photochemical in the extracts. Result for weight loss also revealed that inhibition efficiency increased with increasing inhibitor concentration. Adsorption study revealed that adsorption of the extract of citrullus lanatus on mild steel surface occurred according to Langmuir adsorption isotherm.