Possible Ameliorative Role of Low Dose of Radiation Againstcisplatin Induced Oxidative Stress and Tissue Damage Male Rats (Published)
The present study describes antioxidant effect of low dose of radiation against cisplatin induced toxicity in rats. Oxidative stress was induced in rat by a single dose of cisplatin (10 mg/kg body weight I.P), 24 hr post- cisplatin treatment, the animals exposed to 0.3 Gy single dose of gamma ray. The effect of treatments in influencing the oxidative stress as well as biochemical cisplatin changes on brain, kidney and testis were studied. The data showed significant increase in serum urea, creatinine, creatine kinase isoenzymes (CKBB) and tumor necrosis factor (TNF-α) as well as in tissue MDA levels in animals treated with cisplatin while this effects were attenuated by radiation exposure. Moreover, treatment with cisplatin caused a significant decrease in serum testosterone and tissues SOD activities, which was shown to be reversed by low dose of radiation treatment. Treatment with low dose of radiation significantly reduced the oxidative stress effects induced by cisplatin administration. It can be concluded that exposed animals to a low dose of radiation after cisplatin treatment can speed the recovery of the body during the chemotherapeutic treatment.