Tag Archives: circadian rhythm

The circadian rhythms: role of biological clock in plant growth and development (Published)

Circadian (around the day ) is a complex of two Latin words circa [around] and dies [day]  they are endogenous and adjusted to the local environment by  the daylight cues called Zeitgebers  ZT (Germany for time giver) and  the study of other biological rhythms is called chronobiology .most of metabolic and  physiological processes in plants and animals including humans are going around an internal oscillator in a continuous period of 24h called circadian rhythm and is a diurnal rhythm  this biological clock central loop is composed of the circadian clock components .in plants this circadian rhythm controls processes like photosynthesis , photoperiodism and photo protection  by adjusting the crop with the environment that is why is referred to the master regulator of the plant life. Many researchers have proved that well understanding of the biological clocks can be useful in development of agricultural improved crops .in Arabidopsis as a model plant in plant breeding and development this biological clock has been used to identify some clock related genes which are responsible to the plant growth regulation, germination ,flowering ,biotic and abiotic stress responses and others studies have revealed that tissues and even every single cell is governed by circadian  clock systems .in this review we are discussing our current understanding of the clock and its interactions with light and temperature signaling pathways, the history of clock research development, the circadian clock in Arabidopsis thaliana as a model plant ,its role during biotic and abiotic stresses ,plant hormones and homeostasis and our future perspectives about circadian research.

Keywords: biological clock, circadian rhythm, homeostasis, plant metabolism

Food Intake and Caffeine Determine Amyloid Beta Metabolism with Relevance to Mitophagy in Brain Aging and Chronic Disease (Published)

In the global world diabetes and mitochondrial disease is expected to cost the developing world in the next 30 years US $400 million. In diabetes an absent peripheral sink amyloid beta clearance pathway is now relevant to amyloid beta induced mitochondrial apoptosis. The quality of food consumed has raised major concerns with increased levels of plasma bacterial lipopolysaccharides (LPS) that induces amyloid beta aggregation and mitochondrial apoptosis with programmed cell death linked to non alcoholic fatty liver disease (NAFLD) and many organ diseases. The amount, nature and time of day of fat consumption in diabetes has become important with relevance to caffeine metabolism, brain toxic amyloid beta oligomer formation and neuron apoptosis. To prevent programmed cell death dietary fat and caffeine consumption need to be revised to allow rapid hepatic caffeine and amyloid beta metabolism with the prevention of global mitophagy associated with diabetes, NAFLD and neurodegenerative diseases.

Keywords: Diabetes, amyloid beta, caffeine, circadian rhythm, fat diet, mitochondria