The study investigated adolescence drug abuse among university undergraduates in university of Benin Edo State of Nigeria. The design used for the study was the survey. A sample of 200 students was randomly selected form five faculties which were made up of 100 male and 100 female. A validated instrument, Drug Habit Inventory (DHI, Fayombo, 1998) was used to collect relevant data. The data collected was analyzed using a t-test descriptive statistic. The findings show a significant difference between the adolescence drug abuser and non-drug abuser and also there was a difference between the male abuser and female abuser but there was no statistical significant difference between the academic performance of adolescence drug abuser and non-drug abuser. Based on the findings, recommendations were made on how to reduce drug abuse among the university undergraduate.