The study was carried out in Imo State, Nigeria. The primary objective of the study was among others to estimate the net returns to cassava based crop mixtures in the area. The multi-stage stratified random sampling technique was used in selecting a sample of ninety six respondents from the area. Data collected were analyzed using descriptive statistics and farm budget technique. The result of the analysis show that the net returns to cassava/yam/maize/melon crop mixture was N124,776.58, while the returns per naira invested by the farmer was 46k. The cassava varieties cultivated are TMS 419, TMS 30572, TMS 30555, TMS 4(2) 1425, TMS 98/002, NR 8083, NR 8082, NR 84292, NR 8212, IMO Best, and 98/0581. It was recommended that extension agents should encourage farmers to grow cassava/yam/maize/melon crop mixture since it gave both the highest net return and return per naira invested.