Staff loyalty has always been a matter of concern for organizations. Employee turnover is highly detrimental both the organization as well as the employees. Loyalty has an impact over the organization’s costs relating to recruitment, training of new personnel and others. Private companies have the problem to keep talent and having more employee loyalty. Therefore, the study objective is to find out the determinants affecting the staffs’ loyalty at private companies in Can Tho City (CTC). The researchers surveyed 450 staffs working at private companies and answered 23 questions but sample size of 413 staffs processed. The data collected from August 2018 to March 2019 in CTC. Simple random sampling technique. Cronbach’s Alpha and the exploratory factor analysis (EFA) analyzed and used for Structural Equation Modelling (SEM) technique. Finally, the findings of the study have five factors affecting the staffs’ loyalty at private companies in CTC with significance level 0.01.