Tag Archives: caffeine

Analysis of Faroe spp. and Cyombopogon citratus extracts for their beverage potential vis-a-vis processed black coffee and black tea leaves (Published)

Faroe spp. and Cymbopogon citratus concoctions have continuously been used as beverages in absence of coffee or tea leaves in Kenya. This study aimed at characterizing their extracts for chemical similarities with processed black coffee and tea leaves. Wet chemistry and spectroscopic methods were used to evaluate these similarities. While the physical-chemical properties were closely related, the results indicated resemblance in functional groups, matching those of polyphenols. The Ultra-Violet (UV) spectra indicated abundance of dienes and xanthophyll pigments. Faroe spp. extracts had more antioxidants against 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenger. Phytochemicals and amino acids screens of the samples closely matched those of black coffee and tea. The order of caffeine content was black coffee (398.990, black tea (169.110, Faroe spp. (116.640mg/L) and Cymbopogon citratus (38.760 The same series was observed for total alkaloids and flavonoid content. In conclusion, these extracts were found to have a lot of similarities with black tea and coffee.

Keywords: Cymbopogon citratus, Faroe spp., beverages, caffeine

Effect of Ingestion of Caffeine and Dennettia Tripetala (Pepper Fruit) Seeds on Peak Expiratory Flow Rate in a Nigerian University (Published)

Background:  Caffeine is a known respiratory stimulant. Literatures abound on the medicinal use of Dennettia tripettela seeds but limited literatures of its effect on the airway post caffeine ingestion.  This study is aimed at investigating the combined effect of ingestion of caffeine and Dennettia tripetala seeds on the airway using peak expiratory flow rate (PEFR) index.Study design:  Thirty (30) undergraduates’ students of University of Benin comprising of 15 males and 15 females with age range of 18-25 years, were used for this study. Each Subject was given 2g of caffeine and their PEFR recorded at 30 minutes intervals post ingestion, and subsequently 2g of Dennettia tripetala seeds were given, 2hours post ingestion of Caffeine.  PEFR was also recorded for subjects who ingested 2g of Dennettia tripetala seeds 10 minutes post ingestion. Subjects’ pre administration PEFR was also recorded. All measurements were taken using the Mini Wright peak flow meter. Results: Results showed  that  PEFR was significantly increased (p<0.05) when 2g of caffeine,  2g of pepper fruit seeds were ingested and a much higher increase was observed when 2g of pepper fruit seeds was administered 2hours post ingestion of Caffeine when compared to the control. These increases in PEFR were much more observed in males than in the females’ subjects. Conclusion: This suggests that Dennettia tripetala seeds have bronchodilatory effect and when taken together with Caffeine may be of supportive treatment for the treatment of obstructive or restrictive airway diseases.

Keywords: Dennettia tripetala seeds, PEFR, caffeine

Food Intake and Caffeine Determine Amyloid Beta Metabolism with Relevance to Mitophagy in Brain Aging and Chronic Disease (Published)

In the global world diabetes and mitochondrial disease is expected to cost the developing world in the next 30 years US $400 million. In diabetes an absent peripheral sink amyloid beta clearance pathway is now relevant to amyloid beta induced mitochondrial apoptosis. The quality of food consumed has raised major concerns with increased levels of plasma bacterial lipopolysaccharides (LPS) that induces amyloid beta aggregation and mitochondrial apoptosis with programmed cell death linked to non alcoholic fatty liver disease (NAFLD) and many organ diseases. The amount, nature and time of day of fat consumption in diabetes has become important with relevance to caffeine metabolism, brain toxic amyloid beta oligomer formation and neuron apoptosis. To prevent programmed cell death dietary fat and caffeine consumption need to be revised to allow rapid hepatic caffeine and amyloid beta metabolism with the prevention of global mitophagy associated with diabetes, NAFLD and neurodegenerative diseases.

Keywords: Diabetes, amyloid beta, caffeine, circadian rhythm, fat diet, mitochondria