Tag Archives: Biological Activity

Preparation, Characterization and Study the Biological Activity of New No2, Novel N2o2 Ligands and Their Complexes with [Co (Ii), Cu (Ii), Ni (Ii), Mn (Ii) and Hg (Ii)] Ions (Published)

A new two Schiff bases derivatives was synthesized and characterized with studying their biological activity and employed anganese (II),Cobalt (II),Nickel(II),Copper(II) and Mercury (II) complexes: 2 – ((Z) – 4 – ((Z)-2-hydroxy-1, 2-diphenylethylideneamino)-1, 5 – dimethyl – 2-phenyl-1H-pyrazol-3(2H)-ylideneamino) benzoicacid and (E)-4-(2-hydroxy-1, 2-diphenylethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one. The first ligand were obtained through a reaction of Benzoin and 4-Aminoantipyrine while the second result from the condensation of the first ligand with 2-amino benzoic acid. Ten new coordination compounds were synthesized and structurally characterized: [Co(L1)(Cl)], [Cu(L1)(Cl)] [Ni(L1)(Cl)],[Mn(L1)(Cl)],[Hg(L1)(Cl)],[Co(L2)],[Ni(L2)],[Cu(L2)], [Mn(L2)] and [Hg (L2)]. All of the suggested chemical structures of the prepared ligands and metal complexes are confirmed by using FT- IR, UV, 1H& 13C-NMR spectra. Most of the prepared compounds show antibacterial activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeroginosa).

Keywords: 2-Aminobenzoicacid, 4-Amino Antipyrine, Benzoin, Biological Activity, Characterization, Schiff Bases

Synthesis, Characterization and Biological Activity of Two Phenol- Schiff Bases and Formaldehyde Resin Cobalt (Ii) – Complexes. (Published)

Transition metal, cobalt (II) acetate, complexes of salicylaldehyde derived Schiff bases : 2-{[(2- hydroxophenyl) imino] methyl} phenol (OHMP), 2-{[ (2- carboxy- phenyl) imino] methyl} phenol (COOHMP), and anthranilic acid- formaldehyde resin (R-COOHMP) were synthesized and characterized by various analytical and spectroscopic studies ( FT-IR, UV-Visible and 1H NMR ). The Schiff base ligands,  formaldehyde chelating resin and their Co(II) complexes were also screened for their urease, α – chymotrypsin, acetylcholinesterse and butylrylcholinesterase  inhibition activities. The ligands were found active against two bacterial species: Staphylococcus aureus and Escherichia coli, all theligands and complexes were evaluated for their thermal degradation studies using TG- DTA analytical methods in static air

Keywords: Biological Activity, Cobalt(II)-Complexes, formaldehyde resin

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF TWO PHENOL- SCHIFF BASES AND FORMALDEHYDE RESIN COBALT (II) – COMPLEXES (Published)

Transition metal, cobalt (II) acetate, complexes of salicylaldehyde derived Schiff bases: 2-{[(2- hydroxophenyl) imino] methyl} phenol (OHMP), 2-{[ (2- carboxy- phenyl) imino] methyl} phenol (COOHMP), and anthranilic acid- formaldehyde resin (R-COOHMP) were synthesized and characterized by various analytical and spectroscopic studies ( FT-IR, UV-Visible and 1H NMR ). The Schiff base ligands, formaldehyde chelating resin and their Co(II) complexes were also screened for their urease, α – chymotrypsin, acetylcholinesterse and butylrylcholinesterase inhibition activities.The ligands were found active against two bacterial species: Staphylococcus aureus and Escherichia coli, all theligands and complexes were evaluated for their thermal degradation studies using TG- DTA analytical methods in static air.

Keywords: Biological Activity, Cobalt (II)-complexes., formaldehyde resin

Spectroscopic and Biological Studies of Mn(II),Ni(II),Cu(II) and Cd(II) Complexes With ligand derived from the condensation of dehydroacetic acid and diethylenetriamine (Review Completed - Accepted)

A series of binuclear acyclic polydentate complexes of Mn(II), Ni(II), Cu(II) and Cd(II) ions with a With ligand derived from the condensation of dehydroacetic acid and diethylenetriamine ( 3,3′-[iminobis(ethane-2,1-diylnitrilo(1E)eth-1-yl-1-ylidene)]bis(4-hydroxy-6-methyl-2H-pyran-2-one)]), [Mn2LCl2(H2O4)] and [M2LCl2], M=Ni, Cd and Cu(II), have been prepared and characterized by1H and 13C NMR, FT-IR and UV-Visible spectroscopy and micro-elemental analysis, as well as with the measurement of the magnetic moments of solid complexes and molar conductivity in DMSO solution.

The new acyclic poly dentate ligand 3,3′-[iminobis(ethane-2,1-diylnitrilo(1E)eth-1-yl-1-ylidene)]bis(4-hydroxy-6-methyl-2H-pyran-2-one)]. The isolated free ligand have fully identified on the basis of (CHN) elemental analysis, 1H, 13C NMR, as well as FT- IR and UV-Visible spectroscopy. The antimicrobial activity of the free ligand and its Mn(II), Ni(II), Cu(II) and Cd(II) complexes were tested against Staphylococcus aureus and Escherichia coli and fungicidal activity against Aspergillus Niger and Candida albicans. The minimum inhibitory concentration MIC. method revealed that all metal complexes showed enhanced activity toward the selected micro-organisms compared with the free ligand H2L and Amoxicillin. The octahedral geometry was proposed for Mn(II) complex, square planar for Ni(II) and Cu(II) complexes and tetrahedral symmetry was suggested for Cd(II) complex

 

Keywords: Binuclear Complexes, Biological Activity, Dehydroacetic Acid