Tag Archives: Antibiotic resistant bacteria

Using Dissemination of Antibiotic Resistant Bacteria (ARB) and Resistance Genes (ARG) for Wastewater Treatment (Published)

This investigation was directed to assess the impact of wastewater treatment forms on the pervasiveness of anti-infection obstruction fecal coliform (FC) and anti-toxin opposition qualities (ARGs) of FC. What’s more, the event of anti-infection safe microscopic organisms (ARB) and anti-toxin safe qualities (ARGs) in surface waters accepting wastewater was assessed. More noteworthy opposition against penicillin (P), colistin (CT) and ampicillin (AMP) were watched for FC disconnected from profluent purified by chlorine (71%), than that cleaned by UV (45%). The best opposition against six anti-infection agents was recorded for FC secludes from emanating purified by chlorine. The pervasiveness of test and blaSHV was most reduced in disconnects from chlorine-purified effluents. The event of ARG blaSHV was most astounding in FC disconnected from emanating sterilized by UV. A critical relationship was recorded between FC levels in surface waters and the degree of bacterial protection from ampicillin (P < 0.05) and to chloramphenicol (P < 0.05). AmpC and blaPSE1 were more pervasive than blaSHV in effluents and in surface waters. TetA and tests were profoundly pervasive in surface water contrasted with test. The consequences of the examination exhibit across the board pervasiveness of ARB and ARG in wastewater and accepting water bodies. The outcome shows that the wellspring of ARB and ARG in surface waters start from wastewater. Discharged ARB and ARG may fill in as the wellspring of ARG to pathogenic microscopic organisms in surface waters. Sanitization procedures may impact the choice of anti-infection safe examples of microorganisms.

Keywords: Antibiotic resistant bacteria, Disinfection, Genes, Treatment., wastewater

The Potential Application of Bacteriophages’ Product Therapy as an Alternative Treatment for Antibiotic Resistance Pathogenic Bacteria (Published)

Bacteriophages or phages are viruses that invade only bacterial cells and, in the case of lytic phages, disrupt bacterial metabolism and cause the bacterium to lyse. They are naturally occurring predators of bacteria, ubiquitous in the environment, with high host specificity and capacity to evolve to overcome bacterial resistance which makes them an appealing option for the control of pathogens. Phage therapy involves the use of bacteriophages, viruses that only attack bacteria and are very host specific, to kill pathogenic microorganisms. Phages are self replicating agents that are able to multiply by taking over their host’s DNA replication and protein synthesis machinery. They can possess two life cycles, lytic and lysogenic. Phages were predicted very early as therapeutic tools to fight pathogenic bacteria but the successful and generalized use of antibiotics to control bacterial infections and the difficulties in obtaining purified phage preparations, delayed the use of phages for therapy. Facing the fast emerging and widespread pathogenic bacteria that have acquired resistance to most or all available antibiotics, the World Health Organization  warned that these multiple antibiotic resistant bacterial pathogens will very likely bring the world back to the pre-antibiotics era. The pressing public concern has triggered global efforts in developing novel alternative antibacterials, including bacteriophages and phage encoded lytic enzymes as two families of candidate antimicrobials. Therefore, phages and their products are currently believed to be a potential therapeutic option to treat bacterial infections that do not respond to conventional antibiotics.

Keywords: Antibiotic resistant bacteria, Bacteriophages, Phage encoded lytic enzymes, Phage therapy