Some Pharmacological Activities Of Hexadec-12-Enoic Acid Isolated From Chenopodium Ambrosioides Linn (Published)
The extractive (labelled Sc), from Chenopodium ambrosioides (Linn), which had been characterised as hexadec-12-enoic acid in an earlier work, was tested for analgesic, antipyretic and anti-inflammatory activities. The result for the acetic acid induced writhing test for Sc revealed very high activity, 96.77%, being significantly higher than that of the standard, aspirin i.e. acetyl salicylic acid, (64.68 %). The hot plate analgesic test showed that the activity was not significant and was short-lived compared to that of morphine. The test for antipyretic activity revealed that it possessed not only antipyretic but also hypothermic activity 3 hours after administration. The anti-inflammatory activity of hexadec-12-enoic acid may be involved prostaglandin synthesis inhibition.