Real estate value tends to change continuously over the years. To accurately determine the value of the real estate you target, it is necessary to consider and evaluate based on many different impacts. Demand-supply factor, but the cost of a real estate in the market is also directly affected by factors such as natural element, property location, legal element. Therefore, this paper studied factors affecting real estate values of real estate in Ho Chi Minh City (HCMC). The authors surveyed 500 staffs who are working for real estate companies in HCMC. This paper used a simple random sampling technique, tested Cronbach’s Alpha, the exploratory factor analysis, and Structural Equation Modelling (SEM). The paper used a questionnaire on a 5-point Likert scale. This paper found five factors affecting real estate values of real estate in Ho Chi Minh City (HCMC) with a significance level of 0.01.