Tag Archives: Albino-Rats

Effect of Cassava (Manihot Esculenta, Crantz) Extract on Biochemical Profile of Infected Albino Rats (Published)

This study is designed to evaluate the effect of ethanolic extract of Cassava (Manihot esculenta, crantz) on biochemical profile of Albino Rats. Four varieties of cassava leaves were used: two for sweet cassava (TMS 98/0505, TME 419) and two for bitter cassava (TMS 98/0002, NR 8082).  Eighty Wistar Albino Rats of both sexes weighing 150-200g were used. The animals were orally infected with human intestinal parasites. They were randomly divided into 5 groups and subjected to different treatments. The   results showed that sweet cassava varieties caused significant decrease (P<0.05) in the valves of ALT, ALP and CRT, while bitter cassava varieties caused significant increase (P<0.05) in the levels of ALT, ALP and CRT in the treated groups when compared with control.  The ethanolic extract of the Sweet Cassava Varieties protected the liver and kidney of Albino Rats from damage caused by intestinal parasitic infections. These Varieties are useful phytomedicines for controlling intestinal parasite infections.

Keywords: Albino-Rats, Biochemical Profile, Ethanolic, Human Intestinal Parasites, Manihot Esculenta Crantz, Phytomedicines

Biochemical Evaluation of Harungana Madagascariensis Lam Aqueous Leaf Extract in Diabetic Rats (Published)

Effects of aqueous leaf extract of Harungana madagascariensis Lam. ex Poir (Family: Hypericacea) on alloxan-induced diabetic rats were investigated. 500 mg/kg body weight extract was administered orally twice daily for 7 days. Blood glucose, cholesterol, bilirubin, alanine aminotransferase (ALT) and alkaline phosphatase (AP) levels hitherto raised in diabetic rats consequent upon induction of diabetes, were significantly (p<0.05) reduced following administration of the extract, except for ALT (p>0.05) . In contrast, the significant (p<0.05) decrease in plasma protein of the rats injected with alloxan were significantly (p<0.05) increased by administration of the extract compared to diabetic control rats, suggesting membrane structure and integrity of liver cells were restored. Neither alloxan nor the extract had any significant effect on albumin concentration. The results indicate the aqueous extract of Harungana madagascariensis leaf is antihyperglycaemic and antihypercholesterolaemic justifying its folkloric use as a diabetic agent and appears to have the propensity to restore damaged liver cells back to functionality.

Keywords: Albino-Rats, Biochemical Effects, Diabetes Mellitus, Harungana Madagascariensis Lam, Medicinal Plant

Evaluation Of Beniseed Extract and Fermented Liquor in Treatment of Diarrhoea in Albino Rats Infected with Salmonella Typhi (Published)

The efficacy of fermented beniseed liquor and the methanol extract in treating diarrhoea caused by Salmonella typhi in albino rats orogastrically infected with the bacteria was assessed. At the end of the experiment, haematological, biochemical and liver functioning tests were performed on the blood from the animals. The results obtained from this analysis showed that the selected organism have high infectivity dose, caused a significant reducing effect on the weight of the albino rats and negative effect on the hematological and biochemical parameters assessed. Treatment of infected animals with the fermented liquor and methanol extract of beniseeds showed that both caused a significantly quick recovery of the infected animals from diarrhoea within five days of treatment. However, the rate of recovery was faster with the group of infected rats treated with the fermented beniseed liquor than the extract. Also, treatment with methanol extract of beniseeds also caused a significant increase in the cholesterol level of the blood from the animals. The results obtained from these analyses showed that beniseed have therapeutic properties and that the fermented form is more effective and can be used to treat diarrhoea caused by the selected bacteria used in this study in albino rats.

Keywords: Albino-Rats, Beniseeds, Diarrhoea, Infection, Therapeutic