Tag Archives: 4-Amino Antipyrine

Preparation, Characterization and Study the Biological Activity of New No2, Novel N2o2 Ligands and Their Complexes with [Co (Ii), Cu (Ii), Ni (Ii), Mn (Ii) and Hg (Ii)] Ions (Published)

A new two Schiff bases derivatives was synthesized and characterized with studying their biological activity and employed anganese (II),Cobalt (II),Nickel(II),Copper(II) and Mercury (II) complexes: 2 – ((Z) – 4 – ((Z)-2-hydroxy-1, 2-diphenylethylideneamino)-1, 5 – dimethyl – 2-phenyl-1H-pyrazol-3(2H)-ylideneamino) benzoicacid and (E)-4-(2-hydroxy-1, 2-diphenylethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one. The first ligand were obtained through a reaction of Benzoin and 4-Aminoantipyrine while the second result from the condensation of the first ligand with 2-amino benzoic acid. Ten new coordination compounds were synthesized and structurally characterized: [Co(L1)(Cl)], [Cu(L1)(Cl)] [Ni(L1)(Cl)],[Mn(L1)(Cl)],[Hg(L1)(Cl)],[Co(L2)],[Ni(L2)],[Cu(L2)], [Mn(L2)] and [Hg (L2)]. All of the suggested chemical structures of the prepared ligands and metal complexes are confirmed by using FT- IR, UV, 1H& 13C-NMR spectra. Most of the prepared compounds show antibacterial activity to (Staphylococcus aureus), (Escherichia coli), (Bacillus subtilis) and (Pseudomonas aeroginosa).

Keywords: 2-Aminobenzoicacid, 4-Amino Antipyrine, Benzoin, Biological Activity, Characterization, Schiff Bases