Brain organoids recapitulate in vitro the specific stages of in vivo human brain development, thus offering an innovative tool by which to model human neurodevelopmental disease. Brain organoids can model congenital structural deficits or be subjected to environmental insult. This clinical research and systematic review was conducted for systematically exploring the molecular neuropharmacological and pharmacogenomic mechanisms of the brain organoids, with thorough explanations and analysis of the medical study literature and evidences compiled from the innumerous studies conducted, which explained the multi-dimensional pharmacomolecular significance of brain organoids. The objectives of this study were an observational analytical molecular neuropharmacological research study and a descriptive systematic review on the pharmacogenomic mechanisms of brain organoids.The mixed-method study was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) Statement and Guidelines, 2009, described by the Cochrane Collaboration in June, 2016. At first, the steps of identification included the records which were identified through database searching and the additional records which were identified through other sources. This led to the steps of screening, which included the screened records after the duplicates were removed. From these screened records, few records were excluded, as per the exclusion criteria. Then, in the eligibility step, the full text articles were assessed for eligibility, from which few full text articles were excluded, according to the exclusion criteria, with adequate reasons. This led to the final inclusion step, where the studies were included in the qualitative synthesis of a systematic review, according to the inclusion criteria, and ultimately the studies were included in the quantitative synthesis. An observational analytical molecular neuropharmacological research study was also conducted. In this mixed-method study, the systematic review contributed 3086 refined and relevant medical records, among total 5612 records obtained from the study databases search. It also describes the molecular neuropharmacological and pharmacogenomic mechanisms of brain organoids, which elaborated this descriptive systematic review and observational analytical molecular pharmacological research study. To conclude, this clinical research and systematic review study provided the refined qualitatively synthesised medical records, study literature and databases, as well as a descriptive analysis on the pharmacogenomic mechanisms of brain organoids.
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