The 4.0 industrial revolution (Industry 4.0) will affect almost every sector of the economy, but the degree of impact varies. The most influential are labor-intensive industries such as apparel and electronics. These are industries with hundreds or even thousands of workers, so there will be challenges when automation is increasing. In addition, a higher education organization’s success is influenced by factors’ operating in it’s internal and external environment; a higher education organization can increase it’s success by adopting strategies which manipulate these factors to it’s advantage. A successful higher education organization will not only understand existing factors but also forecast change, so that it can take advantage of change within the environments in which it operates. The study results showed that there were 150 persons who are the managers of higher education organization in Vietnam who interviewed and answered about 13 questions. Data collected from March 2016 to March 2017 for higher education organizations in Vietnam. The paper had been analyzed KMO test, Cronbach’s Alpha and the result of KMO analysis which used for multiple regression analysis. Managers’ responses measured through an adapted questionnaire on a 5-point Likert scale (Conventions: 1: Completely disagree, 2: Disagree, 3: Normal; 4: Agree; 5: completely agree). Hard copy and online questionnaire distributed among 1.000 managers of higher education organization in Vietnam. In addition, the exploratory factor analysis (EFA) results showed that there were three factors, which included of factors following human resource quality (X1), macro environment change (X2), technology capabilities (X3) with significance level 5 percent. In addition, all of three components affecting the higher education organizations’ operation in Vietnam with significance level 5 percent. The research results processed from SPSS 20.0 software.
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