Association between Cytokine Gene Polymorphism and Recurrent Pregnancy Loss among Basra Province Women

Abstract

Forty cases of women sever from recurrent pregnancy loss (RPL) compared with 40 normal women for determining   the cytokine gene polymorphism in the promoter region of : tumor necrosis factor-alpha TNF-α (-308 G/A), interleukin IL-6 (-634 G/C) and IL-10 (-592 C/A) in aborted women of Basra /Iraq. The results indicated that there was an association between RPL and the polymorphisms in inflammatory cytokines (IL-6, TNF-α), while IL-10 gene did not showed  any effect on both cases of RPL and normal cases.

Keywords: Cytokine Genes, IL-10, IL-6, Loss, Recurrent Pregnancy, TNF-α


Article Review Status: Published

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