Neutralizing SARS-CoV-2 Antibody response to 1st dose of AstraZeneca-Oxford AZD1222 Vaccine Among Health Workers in North-Central, Nigeria

Abstract

Speed is an effective catalyst that can differentiate a time of war from other times. Thus, in a global record time of 11 months, the leading COVID-19 vaccine manufacturers completed the first COVID-19 vaccines. However, curbing the epidemic of anti-vaxxers has not been so easy globally. The world, particularly, in Africa has been largely influenced by the myths and conspiracy theories dissuading the public from accepting COVID-19 vaccination as the most effective response against the pandemic. Hesitancy remains the status quo of many Africans to the innovation.This study is centred on findings from a multi-centre study in Ilorin located in North Central, Nigeria among 92 Health Workers (HCWs). The primary objective of the study was to evaluate the efficacy of the first dose of the ChAdOx1 nCoV-19 vaccine. The blood samples of 92 health workers who received their first AstraZeneca-Oxford AZD1222 vaccination dose between March and April 2021 were taken to determine their antibody responses with the hope to ascertain vaccine effectiveness and also to serve as a means of encouragement to Africans in a hope to allay their fears. The overall goal of the study is to provide a scientific basis for advocacy of vaccination in Africa.This study is limited to single dose and owing to scare resources, blood samples were ran once using the cPass kit which is designed based wildtype S protein Receptor Binding Protein (RBD). As a secondary objective, the researchers evaluated but found no association between the level of neutralizing antibodies generated by this first dose and the demographics or the clinical characteristics of the participants. The demographics considered include age (p > 0.05), Gender (p > 0.05) and BMI (p > 0.05). Existing comorbidities of interest in the study were hypertension (p > 0.05), diabetes (p > 0.05) and drug misuse (p >0.05).The study revealed that over 81.5% of the vaccinated study participants mounted a strong neutralizing antibody response to their first vaccine dose, while only about 11% of the study participants had a weak antibody response.

Citation Aisha F. Lawal, Mohammad A. Obeid , Chinedu Egejuru, Adeola Adefioye, Adedapo Adesokan, (2022) Neutralizing SARS-CoV-2 Antibody response to 1st dose of AstraZeneca-Oxford AZD1222 Vaccine Among Health Workers in North-Central, Nigeria, International Journal of Dentistry, Diabetes, Endocrinology and Oral Hygiene, Vol. 4, No,1, pp, 15-24

 

 

 

Keywords: AstraZeneca-Oxford AZD1222 Vaccine, Health Workers, Neutralizing Antibodies, Nigeria, SARS-CoV-2

DOI: https://doi.org/10.37745/ijddeoh.18vo4n1pp1525

Article Review Status: Published

Pages: 15-25 (Download PDF)

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