Serum Homocysteine Levels in Alcoholic Liver Diseases

Abstract

Serum Homocysteine is an intermediate compound of Methionine metabolism. Its effect in liver function is likely to affect the metabolism of both methionine and Homocysteine. These alterations in metabolism; leads to increased serum Homocysteine levels.  Hyperhomocysteinemia is known for its role in cardiovascular diseases; in addition, it’s one of the important risk factors in alcoholic patients. Homocysteine metabolism is dependent on B-complex vitamins like pyridoxine, folate, vitamin-B12. Individuals with mutated methylenetetrahydrofolate reductase (MTHRF) and low folate trap status shows increase in Homocysteine levels. The reduced levels of B12 and folic acid in the cells, increases the serum Homocysteinelevels causing Hyperhomocysteinemia. The aim of present study is to estimate homocysteine levels in alcoholic liver disease (ALD) patients to assess their clinical presentations and to compare and correlate the findings with various types of ALD. In this study 100 alcoholic liver disease subjects and 50 healthy controls were investigated for serum homocysteine (S. Hcy) along with other biochemical parameters. Serum homocysteine levels were marginally increased in all the three groups of alcoholic liver disease subjects in comparison with controls. According to the present study, there are more chances of increased Homocysteine levels in ALD.

Citation: Malapati B., Shaker I.A., Sheth N. (2022) Serum Homocysteine Levels in Alcoholic Liver Diseases, International Journal of Biochemistry, Bioinformatics and Biotechnology Studies, Vol.7, No.1, pp.26-33

Keywords: Alcoholic liver disease, Homocysteine, Hyperhomocysteinemia., Methionine

DOI: https://doi.org/10.37745/ijbbbs.15/vol7n12632

Article Review Status: Published

Pages: 26-32 (Download PDF)

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