Hydrothermal Synthesis and Characterization of Copper Glycinate and Its In Vitro Drugs Adsorption Studies

Abstract

A new porous compound, Copper Glycinate (Bio-MOF-29), [Cu (C2H4NO2)2 (H2O)] has been synthesized by the hydrothermal method and characterized by single crystal XRD analysis. Bio-MOF-29 crystallized in orthorhombic crystal system with P212121 space group. In vitro adsorption studies of four different drugs, terazosin hydrochloride, telmisartan, glimpiride and rosu-vastatin have been carried out for Bio-MOF-29. Drugs adsorption estimations of drugs loaded Bio-MOF-29 have been carried out through High Performance Liquid Chromatography (HPLC), which reveals that these drugs are successfully adsorbed in it. Also the slow release of adsorbed drugs after intervals was observed through HPLC. Thermograms and powder XRD patterns of Bio-MOF-29 before and after drugs adsorption were also recorded to elaborate the phenomenon of drugs adsorption in Bio-MOF-29.

Keywords: : Bio-Metal Organic Framework, Glimpiride, Glycine, High Performance Liquid Chromatography, Single Crystal XRD Analysis, Telmisartan, Terazosine HCl


Article Review Status: Published

Pages: 44-53 (Download PDF)

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