Unlike synthetic drugs plants have different phytoconstituents which can act collectively by which helminths cannot resist them or there could be active constituent(s) in the plant with superior potency. The aim of this study is to investigate the anthemelmintic activity of both crude and fractions of Plumbago zeylanica root extract. Crude extract was subjected to column chromatography from which nine pure compounds were isolated. Chloroform crude extracts recorded less paralysis and death time than ethanolic crude extracts. In addition, the isolated compounds were higher in their anthelmintic activity than crude extracts at almost all concentrations. Both crude and fractions paralyse and kill the worms with less time than that of the positive control and even less than 10 fold especially at low concentrations in case of chloroform extracts.
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